Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.
نویسندگان
چکیده
β-Lap prodrug micelle strategy improves the formulation properties of β-lap therapeutics. The resulting micelles yield apparent high β-lap solubility (>7 mg mL(-1) ), physical stability, and ability to reconstitute after lyophilization. In the presence of esterase, β-lap prodrugs are efficiently converted into parent drug (i.e., β-lap), resulting in NQO1-dependent lethality of NSCLC cells.
منابع مشابه
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.
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ورودعنوان ژورنال:
- Advanced healthcare materials
دوره 3 8 شماره
صفحات -
تاریخ انتشار 2014